NCT00526019

Persistence of Airway Inflammation and Remodeling in Subjects With Symptomatic or Complete Asthma Remission

Characteristics of Symptomatic Asthma Remissions

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 85 (actual)
• Sponsor: Laval University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

This study aims at determining the patterns of asthma remission, the prevalence of these different patterns, the various factors associated with such remissions and possible recurrences of asthma, in order to determine the mechanisms involved in these processes. The investigators therefore want to document these specificities in subjects in complete remission of their asthma, and those in only symptomatic remission of their asthma, in comparison with mildly symptomatic asthmatic subjects and healthy controls.

Detailed description

Primary Outcome Measures : * Airway inflammation (% induced sputum eosinophils) Secondary Outcome Measures: * Perception of induced respiratory symptoms * Airway response to methacholine and AMP, and perception scores * Diurnal variation in Peak Expiratory Flows * Profile of regulatory T cells in the peripheral blood * Changes in these parameters over time (baseline, 6 months, 1 and 2 years)

Conditions

• Asthma

Timeline

• Start date: 2007-09-01
• Primary completion: 2011-06-01
• Completion: 2012-02-01
• First posted: 2007-09-06
• Last updated: 2012-02-22