NCT00525967

Switching From Morphine to Oral Methadone Plus Acetaminophen in the Treatment of Cancer Pain

Switching From Morphine to Oral Methadone Plus Acetaminophen in the Treatment of Cancer Pain: A Randomized, Double-Blind Study

• Status: Unknown
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: Faculdade de Medicina do ABC · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine whether oral methadone plus acetaminophen can substitute morphine in the treatment of cancer pain.

Detailed description

Opioids are the mainstay of moderate-to-severe cancer pain management. Although morphine is the most commonly used, methadone has some advantages such as higher potency, lower cost and longer administration intervals. To minimize the time necessary to achieve the equianalgesic effect after a switching from morphine to methadone, acetaminophen was added in the treatment.

Conditions

• Cancer
• Pain
• Palliative Care

Interventions

Type	Name	Description
DRUG	Methadone plus Acetaminophen or Placebo	Methadone bid according to a established conversion morphine-to-methadone ratio plus Placebo or Acetaminophen qid

Timeline

• Start date: 2006-02-01
• Completion: 2007-10-01
• First posted: 2007-09-06
• Last updated: 2007-09-06

Locations

1 site across 1 country: Brazil