Trials / Completed
CompletedNCT00521573
Effects of Chocolate on Coronary Vasomotion in Patients After Heart Transplantation
- Status
- Completed
- Phase
- Phase 1
- Study type
- Interventional
- Enrollment
- —
- Sponsor
- University of Zurich · Academic / Other
- Sex
- All
- Age
- 20 Years – 80 Years
- Healthy volunteers
- —
Summary
The aim of the present study is to investigate whether the ingestion of a flavonoid-rich dark chocolate compared to flavonoid-free placebo chocolate will improve coronary vasomotion in heart transplanted patients.
Detailed description
Dark chocolate contains a high amount of flavonoids. Flavonoids hold the possibilities to improve oxidative stress and hence the possibility to improve endothelium-dependent coronary vasomotion, which is a powerful surrogate for clinical prognosis. Coronary atherosclerosis is promoted by impaired endothelial function and increased platelet activation. High oxidative stress and reduced antioxidant defenses play a crucial role in the pathogenesis of atherosclerosis, in particular in transplanted hearts. The aim of the present study is to investigate whether the ingestion of a flavonoid-rich dark chocolate compared to flavonoid-free placebo chocolate will improve coronary vasomotion in heart transplanted patients.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Dark chocolate |
Timeline
- First posted
- 2007-08-28
- Last updated
- 2007-08-28
Source: ClinicalTrials.gov record NCT00521573. Inclusion in this directory is not an endorsement.