NCT00521508

Role of Regulatory T Cells in Pathogenesis of Primary IgA Nephropathy

Role of CD4+CD25+FoxP3+ Regulatory T Cells in Pathogenesis of Primary IgA Nephropathy

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 45 (estimated)
• Sponsor: Centre Hospitalier Universitaire de Saint Etienne · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

Along structural IgA abnormalities, hyperproduction of IgA is thought to play a role in the pathogenesis of primary IgA nephropathy. CD4+CD25+Fox3P regulatory T cells are instrumental in suppressing adaptative immune responses, including B cells production of immunoglobulins. We, the researchers at Centre Hospitalier Universitaire de Saine Etienne, will test the hypothesis that IgA production in patients with IgA nephropathy is dysregulated because of a quantitative and/or qualitative defect of CD4+CD25+FoxP3+ regulatory T cells.

Conditions

• Glomerulonephritis, IGA

Interventions

Type	Name	Description
PROCEDURE	gene transcription and cytometry	samply of 30 ml of blood

Timeline

• Start date: 2008-04-01
• Primary completion: 2010-04-01
• Completion: 2010-09-01
• First posted: 2007-08-28
• Last updated: 2010-09-29

Locations

1 site across 1 country: France