NCT00520585

Study of Influence of Atorvastatin on the Repolarisation Phase of Cardiomyocytes

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: —
• Sponsor: Masaryk University · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The aim of this study is to evaluate influence of atorvastin on the repolarisation phase of cardiomyocytes. If there is any, it could be a part of positive "non-lipid" effect of statins in therapy of ischaemic heart disease. Study hypothesis: atorvastin will decrease heterogeneity of repolarisation of cardiomyocytes in comparison with placebo

Detailed description

The group will consist of 40 healthy volunteers. The study will be mono-centric. The repolarisation phase of cardiomyocytes will be evaluated using long - term 12-lead digital ECG monitoring. There will be 3 single ECG recordings - randomly after 20 mg of atorvastin, 80 mg of atorvastatin and placebo, respectively.

Conditions

• Heterogeneity of Cardiomyocytes Repolarisation
• Autonomic Changes of Cardiomyocytes Repolarisation

Interventions

Type	Name	Description
DRUG	atorvastatin	atorvastatin 20 mg once vs. atorvastatin 80 mg once vs. placebo

Timeline

• Start date: 2007-08-01
• Completion: 2007-11-01
• First posted: 2007-08-24
• Last updated: 2007-08-24