NCT00520026

Suicide Prevention by Lithium - the Lithium Intervention Study

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 167 (actual)
• Sponsor: University Hospital Schleswig-Holstein · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to examine the proposed suicide preventive effects of lithium in a randomized controlled trial within a group of individuals with depressive disorders. The hypothesis being tested is that lithium treatment will significantly reduce the risk for another suicide attempt.

Detailed description

Several studies have shown that there is a significantly increased risk of suicide related mortality in patients with a positive history of suicide attempts. This study is the first prospective, randomized, double-blind, placebo controlled multi-center trial focussing on the proposed suicide preventive effects of lithium in patients with suicidal behavior but not suffering from bipolar disorder or recurrent major depressive disorder. Patients with a recent history of a suicide attempt are treated with lithium or placebo during a 12 month-period. The hypothesis is that lithium treatment will lead to a 50 % reduction of suicidal behavior.

Conditions

• Suicide
• Depressive Disorders

Interventions

Type	Name	Description
DRUG	lithium
DRUG	placebo

Timeline

• Start date: 2001-01-01
• Completion: 2006-06-01
• First posted: 2007-08-23
• Last updated: 2007-08-23

Locations

5 sites across 1 country: Germany