NCT00519454

Estrogen and Gender Biased Autoimmunity

Estrogen and Gender Biased Autoimmunity in Systemic Lupus Erythematosus

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 75 (estimated)
• Sponsor: The Center for Rheumatic Disease, Allergy, & Immunology · Academic / Other
• Sex: Female
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

This study involves research to investigate how estrogen affects women of childbearing age and its correlation to Systemic Lupus Erythematosus. The findings from this study might help determine how body cells, called T Cells, react to estrogen. The study will seek to determine if cells from women with Lupus, react differently from cells in persons without Lupus. We will attempt to identify genetic factors that determine the effects of estrogen on Lupus cells.

Detailed description

This is a 3-year study. The total number of subjects enrolled will depend on the results obtained. The subjects will be at least 18 years of age and pre-menopausal. Exclusion to include pregnant women, and all subjects are told not to get pregnant while on study. Also, they cannot take hormones by mouth or patch while on study. The study can include healthy subjects as well. Blood will be drawn (120 ml) four times a year, randomly.

Conditions

• Systemic Lupus Erythematosus

Interventions

Type	Name	Description
OTHER	Peripheral lab draws	100ml blood for analysis, taken no more than 4 times in one year.

Timeline

• Start date: 2005-04-01
• Primary completion: 2013-12-01
• Completion: 2013-12-01
• First posted: 2007-08-22
• Last updated: 2010-09-08

Locations

1 site across 1 country: United States