NCT00518479

Pathophysiological Mechanisms of Hypertensive LVH:Optimising Regression

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 42 (actual)
• Sponsor: University of Leeds · Academic / Other
• Sex: All
• Age: 25 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Uncontrolled high blood pressure can cause heart muscle 'thickening', and this increases the likelihood of complications and death. The high blood pressure explains some but not all of this increase in heart size. This study will investigate the other causes, and will measure the heart muscle 'thickness' very accurately using the latest and most accurate technique called cardiac magnetic resonance imaging (MRI). The best way to treat this heart thickening remains to be determined. We hope to be able to show that by specifically targeting the cause of heart muscle thickening we can reduce its occurrence more effectively than by other standard means of blood pressure treatment

Conditions

• Hypertension
• Left Ventricular Hypertrophy

Interventions

Type	Name	Description
DRUG	Bendroflumethiazide 2.5mg OD; Amlodipine 10mg OD
DRUG	Valsartan 160mg OD; Moxonidine 400mcg OD

Timeline

• Start date: 2003-09-01
• Completion: 2004-04-01
• First posted: 2007-08-20
• Last updated: 2012-08-16

Locations

1 site across 1 country: United Kingdom