NCT00516061

Relationship of Peritoneal Solute Transport Rate With VEGF in Children Undergoing Peritoneal Dialysis

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 40 (estimated)
• Sponsor: Samsung Medical Center · Academic / Other
• Sex: All
• Age: 1 Year – 18 Years
• Healthy volunteers: Accepted

Summary

Vascular endothelial growth factor(VEGF) appears to play a central role in the process leading to peritoneal angiogenesis and increased level of VEGF may contribute to high peritoneal small-solute transport rate (PSTR) in continuous ambulatory peritoneal dialysis (CAPD) patients in adult. In children, lymphatic absorption of solute is greater than adult. VEGF-C is related to lymphogenesis, but its role in peritoneal solute transport rate is not known. In this study, we evaluated possible relationship between dialysate VEGF and VEGF-C levels and PSTR in children.

Detailed description

There was significant correlation between dialysate VEGF165 and VEGF-C levels and significant correlation was noted between dialysate VEGF165 and PSTR. Interestingly, dialysate VEGF-C levels had significant correlation with PSTR. High PSTR seems to be related to elevated VEGF-C and VEGF.

Conditions

• Peritoneal Dialysis

Timeline

• Start date: 2006-12-01
• Completion: 2007-12-01
• First posted: 2007-08-14
• Last updated: 2007-08-14

Locations

1 site across 1 country: South Korea