NCT00515905

One-lung Ventilation: Expression of Pulmonary Inflammatory Mediators

Lung: One-lung Ventilation: Expression of Pulmonary Inflammatory Mediators After Deflation and Re-expansion of the Lung During Thoracic Surgery

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 76 (estimated)
• Sponsor: University of Zurich · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

One-lung ventilation; organ protection; volatile anesthetics One-lung ventilation has become a common procedure for thoracoscopic surgery. Two hypothesis will be tested in this study: 1. Are inflammatory mediators increased in the re-ventilated lung after short-period pulmonary collapse? 2. Does Sevoflurane influence the production of inflammatory mediators in the re-inflated lung? Therefore, this study will elucidate the potential protective effect of a volatile anaesthetic (sevoflurane) on the production of inflammatory mediators by the respiratory compartment of the lung, i.e. the alveolar epithelium. * Trial with immunomodulatory product / biological

Conditions

• Thoracic Surgery With One-lung Ventilation

Interventions

Type	Name	Description
DRUG	Sevoflurane/propofol	Sevoflurane/propofol

Timeline

• Start date: 2004-10-01
• Primary completion: 2007-09-01
• Completion: 2007-09-01
• First posted: 2007-08-14
• Last updated: 2010-09-15

Locations

1 site across 1 country: Switzerland