Trials / Unknown
UnknownNCT00502632
Dornase Alfa and Urokinase for Kids With Pleural Empyema
Multicentre Randomized Double-Blinded Trial of Intrapleural Dornase Alfa and Urokinase vs Urokinase Alone for Complicated Parapneumonic Effusions in Children
- Status
- Unknown
- Phase
- Phase 2 / Phase 3
- Study type
- Interventional
- Enrollment
- 94 (estimated)
- Sponsor
- Azienda Ospedaliera di Padova · Academic / Other
- Sex
- All
- Age
- 1 Year – 16 Years
- Healthy volunteers
- Not accepted
Summary
The purpose of this study is to determine whether intrapleural treatment with Dornase alfa plus Urokinase improves clinical outcome compared to Urokinase alone in children with complicated parapneumonic effusions
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Urokinase and Dornase alfa | Intrapleural administration of: * Urokinase 40,000 in 40ml normal saline, twice daily for 4 days * Dornase alfa 2,500 IU in 25ml normal saline, twice daily for 4 days |
| DRUG | Urokinase | Intrapleural administration of: * Urokinase 40,000 in 40ml normal saline, twice daily for 4 days * 25ml normal saline, twice daily for 4 days |
Timeline
- Start date
- 2007-10-01
- Completion
- 2009-10-01
- First posted
- 2007-07-17
- Last updated
- 2008-05-12
Locations
3 sites across 1 country: Italy
Source: ClinicalTrials.gov record NCT00502632. Inclusion in this directory is not an endorsement.