NCT00494637

The Use of Sodium Bicarbonate in the Prevention of Contrast Induced Nephropathy

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 468 (estimated)
• Sponsor: Lenox Hill Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Preliminary studies have shown a benefit of sodium bicarbonate infusion in decreasing the risk of contrast induced nephropathy with coronary angiography. The investigators plan to randomize 478 patients (with serum creatinine 1.5 mg/dl or greater) undergoing coronary angiography to intravenous isotonic saline or intravenous isotonic sodium bicarbonate beginning one hour before the procedure and for four hours after. The primary endpoint is the development of contrast nephropathy within 48-72 hours after the procedure. Patients with an ejection fraction \<30%, overt CHF, hypokalemia and alkalemia will be excluded.

Conditions

• Contrast Induced Nephropathy

Interventions

Type	Name	Description
DRUG	sodium bicarbonate	isotonic sodium bicarbonate at 3 cc/kg for one hour followed by 2 cc kg/hr for 4 hours

Timeline

• Start date: 2007-07-01
• Primary completion: 2008-12-01
• Completion: 2009-01-01
• First posted: 2007-07-02
• Last updated: 2009-01-28