NCT00493701

"ADAPT" The Adaptation to High Fat Diets Extention

ADAPT-The Adaptation to High Fat Diets

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 72 (actual)
• Sponsor: Pennington Biomedical Research Center · Academic / Other
• Sex: All
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

This study is designed to predict weight gain overtime after a high fat diet.

Detailed description

In the past 3 years we have identified a "thrifty-phenotype" characterized in lean men by an inability to adapt rapidly to a high fat diet and associated with a low maximal VO2 and high fasting insulin. We hypothesize that the individuals with the "thrifty phenotype" are at higher risk for becoming obese, and that exercise may be effective in overcoming this problem. Several questions remain to be answered regarding the "thrifty" phenotype. First, given the large interindividual differences, how can we identify those at the highest risk? What are the distinguishing biochemical, endocrine and environmental characteristics of individuals that store fat when exposed to high fat diets? This is important because if these individuals can be easily identified, then dietary interventions can be targeted to this "at-risk" population. Second, what is different about the individual with the "thrifty phenotype"? Are there cellular pathways that are dysregulated in the skeletal muscle of these individuals when compared to controls? Is the defect intrinsic, i.e. a diminished ability to conserve glucose and oxidize fat in skeletal muscle or alternately, is the phenotype due to environmental, and dietary factors such as inactivity and energy excess? To answer these questions, we have planned a three-year project that aims to: * Characterize the biochemical, endocrine, anthropometric and environmental characteristics of individuals with the "thrifty" phenotype. * Identify the signaling pathways in skeletal muscle that are dysregulated in individuals with the "thrifty" phenotype through mRNA expression profiling in skeletal tissue. * Determine the role of environmental factors such as inactivity and caloric intake vs. intrinsic (genetic) factors in the "thrifty" phenotype.

Conditions

• Healthy

Interventions

Type	Name	Description
BEHAVIORAL	High Fat Diet	Daily eating
BEHAVIORAL	Low Fat Diet	Life style eating habits

Timeline

• Start date: 2016-07-01
• Primary completion: 2020-03-04
• Completion: 2020-03-04
• First posted: 2007-06-28
• Last updated: 2022-09-15

Locations

1 site across 1 country: United States