NCT00491400

Effect of a Fibrate and a Statin on Endothelial Dysfunction

Effect of a Fibrate (Fenofibrate) and a Statin (Atorvastatin) and on Endothelial Dysfunction in Diabetes Mellitus and the Metabolic Syndrome

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 28 (actual)
• Sponsor: Boston University · Academic / Other
• Sex: All
• Age: 30 Years
• Healthy volunteers: Not accepted

Summary

The study will compare the effect of atorvastatin to the effect of fenofibrate on endothelial function in patients with diabetes mellitus or the metabolic syndrome.

Detailed description

The study will compare the effect of atorvastatin to the effect of fenofibrate on endothelial function in patients with diabetes mellitus or the metabolic syndrome. The study is a double blind, placebo controlled, crossover study with the order of treatment randomized. Patients will receive each treatment for 8 weeks with a 1 week rest period between treatment periods. Endothelial function will be tested using non-invasive techniques before and after each treatments. A total of 40 subjects with diabetes or the metabolic syndrome will be enrolled at Boston Medical Center.

Conditions

• Diabetes Mellitus
• Metabolic Syndrome

Interventions

Type	Name	Description
DRUG	Fenofibrate	140 mg/day for 8 weeks
DRUG	Atorvastatin	20 mg/day for 8 weeks

Timeline

• Start date: 2005-09-01
• Primary completion: 2008-12-01
• Completion: 2008-12-01
• First posted: 2007-06-26
• Last updated: 2012-10-24
• Results posted: 2012-10-24

Locations

1 site across 1 country: United States