Trials / Completed
CompletedNCT00487643
Normal Lacritin Levels in Human Tears- Development of a New Clinical Assay
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 100 (estimated)
- Sponsor
- Walter Reed Army Medical Center · Federal
- Sex
- All
- Age
- 21 Years – 55 Years
- Healthy volunteers
- Accepted
Summary
Purpose: to build a library of normal tear lacritin values by collecting tears from normal adult human subjects and to develop a non-invasive clinical assay for lacritin. Such an assay will provide more sensitive indicators of eye disease for clinicians and determine if a particular therapy, such as recombinant lacritin drops, is of benefit.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | Tear Collection | The tear sample will be collected from the left eye of each subject. Subjects wearing contact lenses will be instructed to remove their lenses and wait at least 5 minutes before proceeding with the tear collection procedure. The patient will then be instructed to sit with eyes gently closed for two minutes after instilling one (1) drop of 0.5% proparacaine on the cornea and conjunctiva. Tear collection was accomplished by using a polyester fiber rod wick. This wick will be placed in contact with the tear fluid at the lower cul-de-sac for a minimum time to obtain fluid without irritating the subject's eye approx. for 3 to 5 minutes. |
Timeline
- Start date
- 2008-05-01
- Primary completion
- 2010-10-01
- Completion
- 2014-03-01
- First posted
- 2007-06-18
- Last updated
- 2014-07-11
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT00487643. Inclusion in this directory is not an endorsement.