NCT00485706

Arterial Stiffness and Decreased Bone Buffering Capacity in Hemodialysis Patients

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: —
• Sponsor: Universitaire Ziekenhuizen KU Leuven · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Renal patients have an increased risk for cardiovascular complications. There is also increased vascular calcification and bone metabolism is similarly abnormal in patients with chronic kidney disease. In dialysis patients frequent episodes of hypercalcaemia occur. In a healthy bone structure those episodes of hypercalcemia are buffered by the bone. The absence of bone buffering capacity in dialysis patients can be a mechanism for vascular calcifications.

Detailed description

Study hypothesis. Patient with a higher ∆ Calcium (Calcium post - Calcium pre) have a diminished bone buffering capacity indicative for adynamic bone disease compared with patients with smaller ∆ Calcium. This may result in higher extraosseous calcification and higher pulse wave velocity ∆ PTH/∆ Calcium may reflect the sensitivity and density of the calcium receptors; this may reflect parathyroid "health"

Conditions

• Kidney Disease
• Hypercalcemia

Interventions

Type	Name	Description
PROCEDURE	high calcium dialysate

Timeline

• Start date: 2007-06-01
• First posted: 2007-06-13
• Last updated: 2018-10-17

Locations

1 site across 1 country: Belgium