NCT00478101

Opioid Rotation Versus Combination for Chronic Uncontrolled Cancer Pain

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 2,006 (actual)
• Sponsor: Gachon University Gil Medical Center · Academic / Other
• Sex: All
• Age: 19 Years
• Healthy volunteers: Not accepted

Summary

For cancer patients with inadequate pain relief, a switch to an alternative opioid is the preferred option for symptomatic improvement. However, multiple opioids are often simultaneously administered for anecdotal reasons. The present study isdesigned to assess the analgesic profiles of two different strategies in chronic cancer pain: the opioid rotation from oxycodone to transdermal fentanyl and the combination of oral oxycodone and transdermal fentanyl.

Detailed description

Patients with uncontrolled cancer pain despite treatment of oral morphine equivalent ≥100 mg/d will be randomly assigned to oral opioids to transdermal fentanyl (rotation group) or oral oxycodone plus fentanyl (combination group). Patients answer a questionnaire that included pain severity (0 to 10) and interference items at baseline and after one week. Primary outcomes are change in pain score and treatment success.

Conditions

• Advanced Solid Cancers

Interventions

Type	Name	Description
DRUG	oxycodone fentanyl

Timeline

• Start date: 2006-02-01
• Completion: 2007-04-01
• First posted: 2007-05-24
• Last updated: 2008-03-13