NCT00473603

Effect of Free Fatty Acids (FFA) on Androgen Precursors in Women

Effect of Free Fatty Acids on Androgen Precursors in Vivo in Healthy Young Women

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 13 (actual)
• Sponsor: Charite University, Berlin, Germany · Academic / Other
• Sex: All
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to determine whether free fatty acids modify the androgen levels in healthy young women.

Detailed description

Free fatty acids (FFA) are known to play an important role by inducing insulin resistance and metabolic disturbances in obesity and type 2 diabetes. In addition, FFAs seems to have a stimulatory effect on adrenal androgen precursors in men. However, the effect of FFAs on androgen precursors and androgens in women is yet unknown. Therefore the effect of increased FFAs on adrenal androgens and androgen precursors should be investigated in a randomized controlled cross-over trial.

Conditions

• Hyperandrogenism
• Glucocorticoid Metabolism

Interventions

Type	Name	Description
DRUG	lipid/heparin infusion	to perform an i.v. lipid heparin infusion infusion for 4 h

Timeline

• Start date: 2006-12-01
• Primary completion: 2008-05-01
• Completion: 2008-05-01
• First posted: 2007-05-15
• Last updated: 2018-01-25

Locations

1 site across 1 country: Germany