NCT00471458

Follow-up Study of the RAI-Treated Hyperthyroid Patients

Follow-up Study of Hyperthyroid Patients Treated With RAI in 1965-2002: Morbidity in Long-Term Follow-up

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 5,222 (actual)
• Sponsor: Tampere University · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Previous studies of hyperthyroid patients suggest that they remain at increased risk of cardiovascular morbidity after restoring euthyroidism. The study objective is to compare the rate and causes of hospitalization of hyperthyroid patients treated with radioactive iodine (RAI) with those of an age- and gender-matched reference population in a long-term follow-up study.

Detailed description

A population-based cohort study was conducted among 2611 hyperthyroid patients treated with RAI between 1969 and 2002 in Tampere University Hospital, and among 2611 reference subjects. A reference group was randomly selected, with an age- and gender-matched control subject identified for each patient from the Population Register Centre. The control subject had to be alive at the time when the patient received the first RAI treatment. The causes of hospitalization as well as the diagnosis and date of hospital admission were obtained from the nationwide Hospital Discharge Register (HILMO) maintained by the Research and Development Centre for Welfare and Health (STAKES) using a computerized record linkage, with the personal identification number as the key. The HILMO database covers all dates and causes of hospitalization (hospital admission requiring an overnight stay) of the Finnish citizens since January 1969. New events were analyzed as the main outcome, including only the first hospitalization due to a given indication. The special focus was on the cardiovascular morbidity.

Conditions

• Hyperthyroidism
• Cardiovascular Diseases
• Atrial Fibrillation

Timeline

• Start date: 1969-01-01
• Completion: 2003-12-01
• First posted: 2007-05-10
• Last updated: 2007-05-10

Locations

1 site across 1 country: Finland