NCT00467129

Genes That Affect Disease Outcome in Patients With Metastatic Colorectal Cancer

The Role of Genetic Factors in Clinical Outcome for Colorectal Cancer

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 800 (estimated)
• Sponsor: University of Sheffield · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

RATIONALE: Studying samples of blood and tumor tissue in the laboratory from patients with cancer may help doctors learn more about changes that occur in DNA and help doctors understand how patients respond to treatment. PURPOSE: This clinical trial is examining genes that affect disease outcome in patients with metastatic colorectal cancer.

Detailed description

OBJECTIVES: * Collect blood samples for DNA extraction for genetic studies from patients receiving chemotherapy for metastatic colorectal cancer. * Collect detailed clinical, pathological, and chemotherapy data from these patients. * Identify genetic factors that relate to treatment response and outcome in these patients. OUTLINE: Blood samples are collected and relevant genes and regions are amplified by PCR. PCR products are then sequenced or genotyped for known biological markers and single nucleotide polymorphisms. Tumor samples from surplus pathology specimens are analyzed for expression of candidate genes and mutation in the candidate genes. Clinical and family history data is also collected by questionnaire. PROJECTED ACCRUAL: A total of 800 patients will be accrued for this study.

Conditions

• Colorectal Cancer

Interventions

Type	Name	Description
GENETIC	microarray analysis
GENETIC	mutation analysis
GENETIC	polymerase chain reaction
GENETIC	polymorphism analysis
OTHER	laboratory biomarker analysis
OTHER	questionnaire administration

Timeline

• Start date: 2002-07-01
• First posted: 2007-04-27
• Last updated: 2013-12-18