Trials / Completed
CompletedNCT00466401
Effect of Ezetimibe on Platelet Aggregation and LDL Tendency to Peroxidation
Phase 4 Study on Effect of Ezetimibe on Platelet Aggregation and LDL Tendency to Peroxidation In Hypercholesterolemic Patients on Simvastatin
- Status
- Completed
- Phase
- Phase 4
- Study type
- Interventional
- Enrollment
- 20 (planned)
- Sponsor
- Ziv Hospital · Other Government
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Accepted
Summary
The aim of our study is to Estimate the reduction of LDL by ezetimibe in hypercholesterolemic patients on simvastatin.Investigate the effect of LDL lowering by ezetimibe on platelet activity and LDL tendency to peroxidation in hypercholesterolemic patients on simvastatin therapy The hypothesis is that: 1. LDL lowering by ezetimibe on-top of simvastatin in patients on fixed dose of simvastatin can reduce platelet aggregation, due to the potential decreasing of cholesterol content in the platelet membranes. 2. LDL lowering by ezetimibe can lower LDL tendency to peroxidation.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Simvastatin | |
| DRUG | Ezetimibe |
Timeline
- Start date
- 2005-02-01
- Completion
- 2007-08-01
- First posted
- 2007-04-27
- Last updated
- 2013-02-20
Locations
1 site across 1 country: Israel
Source: ClinicalTrials.gov record NCT00466401. Inclusion in this directory is not an endorsement.