Trials / Completed
CompletedNCT00460044
ADMA and Mechanical Ventilation in Preterm Infants
Plasma ADMA Concentrations at Birth and Mechanical Ventilation in Preterm Infants
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 35 (planned)
- Sponsor
- Amsterdam UMC, location VUmc · Academic / Other
- Sex
- All
- Age
- 32 Weeks
- Healthy volunteers
- Not accepted
Summary
The purpose of this study is to study the relation between mechanical ventilation and ADMA concentrations at birth.
Detailed description
Nitric oxide (NO) plays an important role in the normal development and maturation of the lungs. In addition, NO is an important mediator of vascular smooth muscle relaxation, ventilation perfusion matching, neurotransmission and host defence and bacteriostasis. Asymmetric dimethylarginine (ADMA) is an endogenous derivative of arginine that inhibits NOS and thereby the bioavailability of NO. Preterm infants have increased concentrations of ADMA. Therefore, inhibition of NO by increased concentrations of ADMA which could be associated with reduced pulmonary functioning.
Conditions
Timeline
- Start date
- 2002-01-01
- Completion
- 2003-07-01
- First posted
- 2007-04-13
- Last updated
- 2007-04-13
Source: ClinicalTrials.gov record NCT00460044. Inclusion in this directory is not an endorsement.