NCT00459563

Vitamin D and Blood Pressure

A Randomized Placebo-controlled Double Blinded Trial to Evaluate Cholecalciferol (Vitamin D3) and Calcitriol Treatment on Reducing Blood Pressure in Middle Aged Adults With Stage I Hypertension and Vitamin D Deficiency

• Status: Withdrawn
• Phase: N/A
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Atlanta VA Medical Center · Federal
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

Vitamin D is a natural nutrient in normal daily diet. It can also be made in the skin after exposure to sunlight and is essential for maintaining normal calcium balance. One past study has suggested that vitamin D may be helpful for blood pressure. This study will test whether pills containing cholecalciferol (a form of vitamin D) or calcitriol (the active form of vitamin D) can treat high blood pressure. The investigators plan to enroll up to 80 subjects at the Atlanta VA Medical Center. Participation in the study is expected to last up to 4 weeks. Subjects will be assigned to cholecalciferol, calcitriol or placebo). A 24-hour blood pressure monitor will be worn at the beginning and end of the study to determine blood pressure changes. Renin, PTH, angiotensin-II, and aldosterone levels will also be measured at the beginning and end of the study.

Conditions

• Hypertension

Interventions

Type	Name	Description
DRUG	Vitamin D	200,000 IU once weekly for 3 weeks (600,000 IU total dose)
DRUG	calcitriol	calcitriol 0.5 mcg twice a day for 1 week
DRUG	Placebo	Placebo once a week for 3 weeks

Timeline

• Start date: 2007-03-01
• Primary completion: 2011-12-01
• Completion: 2011-12-01
• First posted: 2007-04-12
• Last updated: 2014-01-08

Locations

1 site across 1 country: United States