NCT00456677

Evaluation of the Utility of Minocycline as an Anti-Inflammatory Agent in the Treatment of Asthma

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: State University of New York - Downstate Medical Center · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Trial of effects of minocycline as "add-on" therapy to adults with asthma with a history of requiring at least one episode of oral steroid therapy to control the disease.

Detailed description

This is a double-blind, placebo-controlled crossover study of adult asthmatics given minocycline 150 mg po BID or placebo as add-on therapy for eight weeks each. Each eight week arm is separated by a four week wash-out. Spirometry is performed at the baseline and end of each arm. Daily symptoms scores, peak flow rates, and oral steroid requirements are recorded. A standardized asthma quality of life symptoms assessment is made every four weeks (AQLQ, Juniper).

Conditions

• Asthma

Interventions

Type	Name	Description
DRUG	minocycline	addition of antibiotic minocycline as antiinflammatory agent in addition to standard of care regimen.
DRUG	Placebos	Addition of oral placebo capsule in addition to standard of care regimen

Timeline

• Start date: 1996-06-01
• Primary completion: 2007-10-01
• Completion: 2007-10-01
• First posted: 2007-04-05
• Last updated: 2017-04-18

Locations

1 site across 1 country: United States