NCT00455026

Effect of Remifentanil on Electroencephalographic BAR Index During Propofol Anaesthesia

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 45 (actual)
• Sponsor: Melbourne Health · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

Current cortical EEG based depth of anaesthesia monitors do not accurately reflect the effect of opioid drugs. We have developed a new theoretically-based method of analysing the EEG. Our hypothesis is that this new method will more accurately predict depth of anaesthesia than the Bispectral Index (BIS) monitor in patients having elective surgery.

Detailed description

Patients aged 18-60 years presenting for elective surgery under general anaesthesia will be recruited. They will be randomised to receive remifentanil effect-site target 0, 2 or 4 ng/ml. Then anaesthesia will be induced with propofol. Loss of the eyelash reflex, response to command and response to electrical stimulation will be measured. The raw EEG will be recorded and analysed off-line using our new method and also for BIS values. Anaesthesia will then proceed according to the needs of the patient and the surgery.

Conditions

• Depth of Anaesthesia

Interventions

Type	Name	Description
DRUG	remifentanil	target effect site concentration during induction

Timeline

• Start date: 2006-03-01
• Primary completion: 2007-10-01
• Completion: 2007-10-01
• First posted: 2007-04-03
• Last updated: 2013-05-30

Locations

2 sites across 1 country: Australia