NCT00452855

Sevoflurane-Remifentanil Anaesthesia. The Risk of Post Operative Nausea

Postoperative Nausea and Vomiting Are Similar When Propofol or Sevoflurane Are Used as Adjuvant to Remifentanil During Anaesthesia for Gynaecological Surgery

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 160 (planned)
• Sponsor: Central Jutland Regional Hospital · Academic / Other
• Sex: Female
• Age: 18 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine whether sevoflurane-remifentanil anaesthesia is similar to propofol-remifentanil anaesthesia concerning post- operative nausea and vomiting.

Detailed description

Propofol and sevoflurane anaesthesia are used world wide at the anaesthetists discretion. Propofol is superior to inhalational anaesthetics as anaesthesia for patients at risk of post operative nausea and vomiting (PONV) as PONV is diminished. However, when remifentanil is used as adjuvant to sevoflurane, the total dose of the latter is reduced. Therefore, we wanted to investigate if sevoflurane-remifentanil anaesthesia is similar to propofol-remifentanil anaesthesia with emphasis on nausea, vomiting and total PONV during 24 hours. In the post anaesthesia care unit (PACU) and in the surgical ward nausea was scored on a visual analogue score. Vomiting was registered.

Conditions

• Nausea
• Vomiting

Interventions

Type	Name	Description
PROCEDURE	Sevoflurane-remifentanil anaesthesia

Timeline

• Start date: 2002-01-01
• Completion: 2005-05-01
• First posted: 2007-03-28
• Last updated: 2007-03-29

Locations

1 site across 1 country: Denmark