NCT00449423

Metabolic Modulation as Treatment in Acute Heart Failure

• Status: Terminated
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 32 (estimated)
• Sponsor: University of Aarhus · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

The primary objective of this study is to evaluate whether metabolic modulation improves hemodynamics and outcome in acute heart failure

Detailed description

Acute heart failure is a serious disease that despite modern therapies carries a high mortality. Inotropic drugs improve patient status but yield a higher risk of death. Previous studies have shown that myocardial contractility improves when glucose fermentation is up regulated and decreases when Free Fatty Acids are high. In a placebo-controlled design we wish to shift myocardial substrate metabolism towards increased glucose uptake and utilization and measure hemodynamics and biochemical markers of metabolism and prognosis.

Conditions

• Acute Heart Failure

Interventions

Type	Name	Description
DRUG	acipimox

Timeline

• Start date: 2007-03-01
• Completion: 2007-10-01
• First posted: 2007-03-20
• Last updated: 2007-10-25

Locations

1 site across 1 country: Denmark