NCT00446563

Efficacy and Safety of Valsartan in Combination With Amlodipine Compared to Losartan Plus Hydrochlorothiazide in Patients With Hypertension and Left Ventricular Hypertrophy

An Open-label, Randomized, Parallel Group Study Comparing the Efficacy and Safety of Amlodipine in Combination With Valsartan Compared to Losartan in Combination With Hydrochlorothiazide Given for 52 Weeks on the Regression of Left Ventricular Hypertrophy in Patients With Mild to Moderate Hypertension

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 90 (actual)
• Sponsor: Novartis · Industry
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

This study will evaluate the safety and efficacy of amlodipine plus valsartan in patients with hypertension and left ventricular hypertrophy

Conditions

• Hypertension; Hypertrophy, Left Ventricular

Interventions

Type	Name	Description
DRUG	Valsartan	160 mg film coated tablets taken orally once daily in the morning.
DRUG	Amlodipine	5 mg or 10 mg tablets taken orally once daily in the morning.
DRUG	Hydrochlorothiazide	12.5 mg or 25 mg tablets taken orally once daily in the morning.
DRUG	Losartan	100 mg tablets taken orally once daily in the morning.

Timeline

• Start date: 2007-03-01
• Primary completion: 2010-03-01
• Completion: 2010-03-01
• First posted: 2007-03-13
• Last updated: 2011-05-11
• Results posted: 2011-04-27

Locations

1 site across 1 country: Germany