NCT00446498

CPAP Versus NPPV in ACPE

Continuous Positive Airway Pressure Versus Non-Invasive Positive Pressure Support Ventilation in Acute Cardiogenic Pulmonary Oedema: a Prospective Randomised Multicentre Trial.

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 80 (planned)
• Sponsor: Ospedale S. Giovanni Bosco · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

To assess the intubation rate in patients affected by severe cardiogenic pulmonary edema treated with CPAP or NPPV.

Detailed description

Background Although non-invasive ventilation has shown to be an effective treatment for acute cardiogenic pulmonary oedema (ACPO), literature still lacks of multi-centre randomised prospective studies that compares CPAP with NPPV. Aim of the study was to assess efficacy and safety of CPAP and NPPV in patients with ACPO. Methods 80 patients with ACPO were randomly assigned to receive CPAP or NPPV (40 for each group) through a face mask. Inclusion criteria were: severe dyspnoea, respiratory rate \> 30, PaO2/FiO2 \< 200, muscle fatigue. Main end-points were endotracheal intubation, length of ventilation, hospital length of stay and mortality.

Conditions

• Pulmonary Edema

Interventions

Type	Name	Description
DEVICE	CPAP and Non Invasive Ventilation

Timeline

• Start date: 2002-07-01
• Completion: 2005-05-01
• First posted: 2007-03-13
• Last updated: 2007-04-03

Locations

1 site across 1 country: Italy