NCT00446212

Dreaming and EEG Changes During Anaesthesia Maintained With Propofol or Desflurane

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 300 (actual)
• Sponsor: Melbourne Health · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

We hypothesise that patients who receive propofol for maintenance of anaesthesia will report dreaming more often when they emerge from anaesthesia than patients who receive desflurane for maintenance of anaesthesia.

Detailed description

Patients commonly report that they have been dreaming when they emerge from anaesthesia. Data from observational studies and small randomised trials suggests that reports of dreaming are more commonly made after anaesthesia maintained with propofol than anaesthesia maintained with inhaled anaesthetic agents. We propose to randomise 300 healthy patients to receive a standardised general anaesthetic for surgery that includes either propofol or desflurane for maintenance. We will measure the raw and processed electroencephalogram during and after anaesthesia and interview patients about dreaming as soon as they emerge from anaesthesia.

Conditions

• Anaesthesia

Interventions

Type	Name	Description
DRUG	Propofol	target controlled infusion of propofol
DRUG	desflurane	Anaesthetic maintenance with desflurane

Timeline

• Start date: 2006-08-01
• Primary completion: 2008-07-01
• Completion: 2008-07-01
• First posted: 2007-03-12
• Last updated: 2013-05-30

Locations

4 sites across 2 countries: Australia, New Zealand