NCT00443833

Genetic Analysis of Thyrotoxic Periodic Paralysis

Genetic Analysis of Thai Patients With Thyrotoxic Periodic Paralysis

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 80 (planned)
• Sponsor: Ramathibodi Hospital · Academic / Other
• Sex: Male
• Age: 15 Years
• Healthy volunteers: Not accepted

Summary

Thyrotoxic periodic paralysis (TPP) is characterized by episodes of reversible hypokalemia and weakness in thyrotoxic patients. It is commonly found in males of Asian descent and is also seen in individuals having Native American or Hispanic ancestry. Therefore genetic etiology has been hypothesized. This study, we aim to find the susceptibility genes that associate with TPP. Both candidate genes approach and genome wide association study have been conducted.

Detailed description

This study is a genetic association study. It included 50 cases of TPP patients and 80 cases of male, hyperthyroid patients who didn't have hypokalemia as a well characterized controls. After informed consent were obtained, genomic DNA from leukocyte were extracted. Pooled DNA were constructed and whole genome scan using 10K GeneChip microarray were genotyped on pooled genomic DNA.

Conditions

• Thyrotoxic Periodic Paralysis

Timeline

• Start date: 2004-01-01
• Completion: 2005-12-01
• First posted: 2007-03-06
• Last updated: 2007-03-06