NCT00441961

Treatment With High Dose Methotrexate in Patients With Eosinophilic Fasciitis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 6 (actual)
• Sponsor: Radboud University Medical Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Evaluate the effect of high dose MTX on skin induration in patients with eosinophilic fascia.

Detailed description

Eosinophilic fasciitis (EF)is a fibrosing skin disorder extensively involving the deep fascia. The aim of this pilot study is to evaluate the effect of high dose MTX on skin induration in patients with EF. In addition, we study the effect of this treatment on joint mobility, peripheral blood eosinophilia, functional ability, and pulmonary function. By administering high dose MTX intravenously every four weeks with a Leukovorin rescue, we hope to induce a more pronounced and sustained effect on the involved skin with less (long-lasting) side effects.

Conditions

• Fasciitis

Interventions

Type	Name	Description
DRUG	methotrexate	methotrexate

Timeline

• Start date: 2006-10-01
• Primary completion: 2010-12-01
• Completion: 2011-06-01
• First posted: 2007-03-01
• Last updated: 2011-08-11

Locations

1 site across 1 country: Netherlands