NCT00437996

Comparative Affect of a Continuous Epidural Infusion of Clonidine During Labour. Prospective Double Blind Randomized Trial

Epidural Analgesia During Labour. Impact of Clonidine Addition to Levobupivacaine and Sufentanil

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 85 (actual)
• Sponsor: Hospices Civils de Lyon · Academic / Other
• Sex: Female
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Addition of clonidine to an epidural mixture of local anaesthetic and morphine improves analgesia and reduces the frequency of motor blockade during epidural analgesia. several side effects are possible mostly somnolence and hypotension. Association of continuous clonidine infusion with low concentrations of levobupivacaïne and sufentanil was not studied during labour. The objective of this study is to compare the effectiveness and the side effects of a PCEA with levobupivacaïne 0,0625 % and sufentanil 0.25 microg.ml-1, without addition of clonidine, and with addition of clonidine at a concentrations of 2 microg.ml-1.

Conditions

• Normal Pregnancy

Interventions

Type	Name	Description
DRUG	Clonidine
DRUG	Levobupivacaine
DRUG	Sufentanil

Timeline

• Start date: 2007-02-01
• Completion: 2008-01-01
• First posted: 2007-02-21
• Last updated: 2009-06-30

Locations

2 sites across 1 country: France