NCT00435994

Assessment of Airway Obstruction in Infants With Lower Respiratory Infections

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 59 (actual)
• Sponsor: Indiana University School of Medicine · Academic / Other
• Sex: All
• Age: 2 Months – 2 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to evaluate how two different aerosol medications may improve airway function in infants with respiratory illness. We are using two different medications and comparing the difference in lung function after each medication. We will also be taking a nasal wash sample for VEGF. We will be using this in comparing how infants respond to the aerosol medications as well. We hope to help standardize medications used for infants with bronchiolitis and RSV.

Detailed description

We hypothesize that VEGF production is higher in children with RSV infection than in children with other viral infections and normal controls. In addition, the degree of VEGF production is related to severity of airway obstruction. We also hypothesize that infants with higher VEGF levels are more likely to improve lung function following racemic epinephrine than albuterol.

Conditions

• Bronchiolitis
• Respiratory Syncytial Virus Infections

Interventions

Type	Name	Description
DRUG	Inhaled primatene will be given as a breathing treatment	While the research subject is sedated an inhaled mist of primatene mist will be given to the patient.
OTHER	Nasal Washing	1-3 mls of normal saline will be instilled into the infant's nose and then aspirated to obtain the nasal fluid, which will be analyzed for VEGF level by ELISA and viral antigens by immunoflourescence

Timeline

• Start date: 2003-12-01
• Primary completion: 2009-03-01
• Completion: 2012-12-01
• First posted: 2007-02-16
• Last updated: 2016-06-01
• Results posted: 2016-06-01

Locations

1 site across 1 country: United States