NCT00435864

Natural Killer Index From Hematopoietic Stem Cell Graft

Pilot, Multicenter and Prospective Study of the Natural Killer Index From Hematopoietic Stem Cell Graft at a Genotypic, Phenotypic and Functional Level

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 92 (actual)
• Sponsor: Nantes University Hospital · Academic / Other
• Sex: All
• Age: 1 Year
• Healthy volunteers: Accepted

Summary

Numerous studies about the potential role of NK alloreactive during a n hematopoietic stem cells graft are based on genotypical analyses of the KIR receptors and on genotypic incompatibilities between KIR and HLA for couple donor/recipient. There is still a lot of issues non resolved: Are KIR really expressed and how occur their expression during time when hematopoietic reconstitution? Is it depending on HLA of the recipient?If KIR are expressed, what are the mechanisms of alloreactivity of NK cells? Are NK able to lyse tumoral cells? Could alloreactive NK cells constitute a therapeutic tool able to induce tolerance and elimination of leukemia during hematopoietic stem cells grafts?

Conditions

• Acute Lymphoblastic Leukemia
• Acute Myeloblastic Leukemia
• Chronic Myeloid Leukemia

Interventions

Type	Name	Description
PROCEDURE	Blood test	The study of KIR and HLA genes will be performed on samples of cord blood or peripheral blood donor and recipient before transplant For grafts from placental cord blood, we do ask any additional samples.

Timeline

• Start date: 2007-04-01
• Primary completion: 2013-11-01
• Completion: 2013-11-01
• First posted: 2007-02-16
• Last updated: 2014-04-30

Locations

1 site across 1 country: France