NCT00434200

Rheumatoid Arthritis Patients in Training

Interventional Study on the Effectiveness and Safety of Intensive Exercise in Patients With RA

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 300 (planned)
• Sponsor: Leiden University Medical Center · Academic / Other
• Sex: All
• Age: 17 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Aim of the study was to investigate the effectiveness (functional ability and physical capacity) and safety (disease activity and damage of the joints) of long-term high-intensity weight-bearing exercises in patients with rheumatoid arthritis (RA).The training proved to be safe and effective.

Detailed description

The 300 patients with RA were randomized into two groups; exercise group and usual care group. The patients who participated in the 2 years intensive exercise training (2 times a week, training duration 65 minutes) improved their functional capacity and functional ability without detrimental effects on the large joints damage or on disease activity. Only patients with excessive large joint damage at baseline were at risk to develop additional damage when participating in intensive weight-bearing exercises. Patients who exercised were able to delay the decrease of bone mineral density of the hips.

Conditions

• Rheumatoid Arthritis

Interventions

Type	Name	Description
PROCEDURE	long-term intensive exercise

Timeline

• Start date: 1998-01-01
• Completion: 2000-06-01
• First posted: 2007-02-13
• Last updated: 2007-02-13