NCT00433121

Discontinuation of Antipsychotics and Antidepressants Among Patients With BPSD

Discontinuation of Antipsychotics and Antidepressants Among Patients With Dementia and BPSD Living in Nursing Homes - an Open Study.

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: Sykehuset Innlandet HF · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

The aim of this study is to discontinue antipsychotics and antidepressants, and to study its effect on Behavioural- and Psychological Symptoms in Dementia (BPSD).

Detailed description

Patients with dementia have cognitive deficits, but also hallucinations, delusions, agitation, aggression and apathy. These symptoms are called Behavioural- and Psychological Symptoms in Dementia (BPSD), and are difficult to treat. Antipsychotic and antidepressant medication is in use, despite its lack of clinical evidence. We will discontinue antipsychotics in one group of 12 patients and antidepressants in one group of 12 patients. Patients should have dementia of Alzheimer- or vascular origin. They should live in Nursing Homes and have no other psychiatric disease for which they receive psychotropic drug. They will be registered with 7 different questionnaires at baseline and after 3, 6, 12 and 24 weeks. The study period is 24 weeks. The questionnaires are filled in by the patients and the nurses at the nursing homes. This is an open labelled study with no control group. Based on the results of this study, we will design a RCT study with placebo-controlled group.

Conditions

• Dementia

Interventions

Type	Name	Description
DRUG	Risperidone
DRUG	Olanzapine
DRUG	Haloperidole
DRUG	Quetiapin
DRUG	Escitalopram
DRUG	Citalopram
DRUG	Sertralin

Timeline

• Start date: 2006-09-01
• Completion: 2007-08-01
• First posted: 2007-02-09
• Last updated: 2007-08-24

Locations

1 site across 1 country: Norway