NCT00422448

Study to Test Genetic Alterations Among Different Dermoscopic Types of Melanocytic Nevi.

BRAF and Nevi.Nevi Are Common Benign Pigmented Tumors of the Skin. Mutations in So-called BRAF and NRAS Genes Genes Appear to be Initiating Events Responsible for the Formation of Nevi.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 43 (actual)
• Sponsor: Medical University of Graz · Academic / Other
• Sex: All
• Age: 9 Years – 80 Years
• Healthy volunteers: Accepted

Summary

This project is a multicenter study in which we will investigate a dual concept of nevogenesis. Study location is the Department of Dermatology at the Medical University of Graz in collaboration with centers in Austria (Vienna), Italy (Naples, Benevento, Modena), Spain (Barcelona) and the United States (New York). The hypothesis is that small congenital melanocytic nevi (CMN), "early" acquired melanocytic nevi in childhood (AMN) and dermal nevi, all dermatoscopically characterized by globular pattern, belong to the same spectrum of genetically determined melanocytic proliferations that develop due to endogenous pathways, in contrast to "true" acquired melanocytic nevi, dermatoscopically showing reticular pattern, that develop due to exogeneous factors such as UV-exposure.

Detailed description

The investigations to this study will verify whether small CMN, "early" AMN and dermal nevi, characterized by globular pattern differ in their genetic alterations compared to reticular typed nevi. It will be expected that globular typed nevi and eventually dermal nevi lack B-RAF mutations whereas reticular nevi show alterations in the B-RAF gene. Study location: Graz

Conditions

• Nevi

Interventions

Type	Name	Description
GENETIC	To test the frequency of BRAF and NRAS mutations among nevi	Benign nevi excised for the study purpose where genetically analyzed for the presence/absence of BRAF and NRAS mutations

Timeline

• Start date: 2006-09-01
• Primary completion: 2009-03-01
• Completion: 2010-04-01
• First posted: 2007-01-17
• Last updated: 2011-01-14
• Results posted: 2011-01-14

Locations

1 site across 1 country: Austria