NCT00420654

Growth Hormone Treatment of Women With Turner Syndrome

Growth Hormone Treatment of Women With Turner Syndrome: Body Composition and Heart Function.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (estimated)
• Sponsor: Britta E. Hjerrild · Academic / Other
• Sex: Female
• Age: 20 Years – 40 Years
• Healthy volunteers: Not accepted

Summary

Growth hormone treatment is used in girls with Turner syndrome to increase final height. The aim of this study is to evaluate the effect of growth hormone treatment on body composition and heart function in adult women with Turner syndrome. The hypothesis is that the fat mass will decrease and lean body mass will increase. There is only very limited documentation of the effect on the heart in this study population.

Detailed description

This study is a randomised, double-blinded, controlled clinical trial to evaluate the effect of growth hormone (GH) treatment on adult women with Turner syndrome. The endpoints will be changes in body composition and heart function evaluated by echocardiography (ECHO) and positron emission tomography (PET). Phase one: 6 months of GH or placebo treatment. Phase two: "open label" all participants are treated with GH for 12 months. At baseline, healthy controls will be examined, but will not receive any treatment

Conditions

• Turner Syndrome

Interventions

Type	Name	Description
DRUG	Growth Hormone	1.25 mg, 6 months
DRUG	Placebo	Equivalent to 1.25 mg, 6 months
OTHER	Healthy controls	Healthy controls

Timeline

• Start date: 2007-08-01
• Primary completion: 2011-09-01
• Completion: 2011-09-01
• First posted: 2007-01-11
• Last updated: 2011-11-08

Locations

1 site across 1 country: Denmark