NCT00415493

Nasal Physiologic Reactivity of Nonallergic Rhinitics to Cold Air Provocation

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: Associated Scientists to Help Minimize Allergies · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

This study seeks to compare patients with vasomotor rhinitis ("perennial nonallergic rhinitis," "idiopathic rhinitis") with normal controls with respect to their nasal physiologic reactivity to cold air challenge. Ten vasomotor rhinitis (VMR) patients with nasal symptoms triggered predominantly by cold air, four VMR patients with symptoms triggered predominantly by chemicals, and ten nonallergic, non-rhinitic control subjects will be studied.

Detailed description

After initial screening and verification that subjects can cooperate with active posterior rhinomanometry, subjects will be scheduled for two 15-minute exposure sessions with either: cold-dry air, or warm-moist air. Subjects will rate symptoms (and have their nasal airway resistance measured in triplicate) prior to exposure and at 15-min. intervals post-exposure until an hour has passed.

Conditions

• Vasomotor Rhinitis

Interventions

Type	Name	Description
OTHER	Cold-dry air provocation	15 minute exposure to cold-dry air by nasal mask
OTHER	Warm-moist air provocation	15 minute exposure to warm-moist air by nasal mask

Timeline

• Start date: 2006-12-01
• Primary completion: 2007-10-01
• Completion: 2008-05-01
• First posted: 2006-12-25
• Last updated: 2017-03-06
• Results posted: 2012-10-26

Locations

1 site across 1 country: United States