NCT00411827

Goblet Cell Response and Dry Eye Symptoms After PRK and LASIK

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 146 (estimated)
• Sponsor: Walter Reed National Military Medical Center · Federal
• Sex: All
• Age: 21 Years – 40 Years
• Healthy volunteers: Accepted

Summary

Purpose: To develop a screening metric by examining both the characteristics of the preoperative tear film and the intracellular signaling pathways of conjunctival goblet cells in order to determine if there are certain characteristics which might predict those patients who will experience serious dry eye symptoms and complications after refractive surgery. Research Design: This study is a twelve-month prospective non-randomized investigation. Methodology: In conjunction with psychometric questionnaires and various measures of tear film quality (e.g. Schirmer's test, tear break up time, etc), impression cytology will be used to assess the intracellular signaling pathways of conjunctival goblet cells and to determine if alterations in this pathway exist. Alterations in this pathway would result in a reduced response by the mucin secreting conjunctival goblet cells thereby promoting the development of dry eye after refractive surgery.

Conditions

• Keratoconjunctivitis Sicca

Interventions

Type	Name	Description
PROCEDURE	PRK with conjunctival impression cytology before and after surgery
PROCEDURE	LASIK with conjunctival impression cytology before and after surgery	LASIK with conjunctival impression cytology before and after surgery

Timeline

• Start date: 2008-01-01
• Primary completion: 2011-02-01
• Completion: 2016-05-01
• First posted: 2006-12-15
• Last updated: 2024-09-20

Locations

1 site across 1 country: United States