NCT00404833

Mycophenolate Mofetil in Membranous Nephropathy and Focal Segmental

A Prospective Randomized Open-label Study to Compare Mycophenolate Mofetil and Corticosteroid With Conventional Immunosuppressive Treatment on Proteinuria in Idiopathic Membranous Nephropathy (MN) and Focal Segmental Glomerulosclerosis (FSGS)

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 16 (estimated)
• Sponsor: Hospital Authority, Hong Kong · Other Government
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: —

Summary

This is a prospective randomized open-label pilot study to investigate the effect of mycophenolate mofetil treatment in patients with abnormal urine protein excretion due to membranous nephropathy (MN) or focal segmental glomerulosclerosis (FSGS). The change in urine protein excretion will be the primary outcome studied. The treatment regimen comprising prednisolone and mycophenolate mofetil will be compared with prednisolone and chlorambucil in MN, and compared with prednisolone in FSGS. The study duration will be 12 months for each patient.

Conditions

• Glomerulonephritis, Membranous
• Glomerulosclerosis, Focal

Interventions

Type	Name	Description
DRUG	prednisolone and mycophenolate mofetil
DRUG	prednisolone and chlorambucil

Timeline

• Start date: 2003-01-01
• Completion: 2006-12-01
• First posted: 2006-11-29
• Last updated: 2013-10-23

Locations

1 site across 1 country: China