NCT00402519

APBI Versus EBRT Therapy After Breast Conserving Surgery for Low-risk Breast Cancer

Interstitial Brachytherapy Alone Versus External Beam Radiation Therapy After Breast Conserving Surgery for Low-risk Invasive Carcinoma and Low-risk Ductal Carcinoma in Situ (DCIS) of the Female Breast

• Status: Unknown
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 1,300 (actual)
• Sponsor: University of Erlangen-Nürnberg Medical School · Academic / Other
• Sex: Female
• Age: 40 Years
• Healthy volunteers: Not accepted

Summary

To assess the role of interstitial brachytherapy alone compared to whole breast irradiation in a defined low-risk group of invasive breast cancer or ductal carcinoma in situ concerning local failure (all ipsilateral local recurrences) to affirm the hypothesis that local control rates in each arm are equivalent.

Detailed description

To assess the role of interstitial brachytherapy alone compared to whole breast irradiation in a defined low-risk group of invasive breast cancer or ductal carcinoma in situ concerning local failure (all ipsilateral local recurrences) to affirm the hypothesis that local control rates in each arm are equivalent.

Conditions

• Breast Cancer

Interventions

Type	Name	Description
RADIATION	Accelerated partial breast irradiation	APBI with PDR and HDR brachytherapy
RADIATION	External beam whole breast irradiation	Standard Whole breast irradiation

Timeline

• Start date: 2004-11-01
• Primary completion: 2009-11-01
• Completion: 2019-11-01
• First posted: 2006-11-22
• Last updated: 2016-05-13

Locations

11 sites across 5 countries: Austria, Germany, Hungary, Poland, Spain