NCT00401336

Quantification of Liver Iron Overload and Steatosis Using Magnetic Resonance Imaging

Quantification of Liver Iron Overload and Steatosis Using a New Magnetic Resonance Imaging Multiecho Gradient-echo Sequence

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 250 (estimated)
• Sponsor: Rennes University Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Iron excess is increasingly regarded as an important cofactor in the morbidity attributed to many disorders. Assessment of body iron stores by measurement of serum ferritin concentrations has poor specificity and the most reliable method is histological or biochemical assessment from a liver biopsy. Because liver biopsy is an invasive procedure, imaging methods have been developed to detect and quantify hepatic iron content. The aim of the study is to use a simplified magnetic resonance imaging (MRI) technique to quantify simultaneously iron and fat contents in the liver and to compare the results to the quantification obtained biochemically.

Detailed description

Iron excess is increasingly regarded as an important cofactor in the morbidity attributed to many disorders. Assessment of body iron stores by measurement of serum ferritin concentrations has poor specificity and the most reliable method is histological or biochemical assessment from a liver biopsy. Because liver biopsy is an invasive procedure, imaging methods have been developed to detect and quantify hepatic iron content. The aim of the study is to use a simplified magnetic resonance imaging technique to quantify simultaneously iron and fat contents in the liver and to compare the results to the quantification obtained biochemically. Patients who need a liver biopsy will be proposed to be enrolled in the study. A magnetic resonance (MR) study will be performed using breath-hold gradient echo sequences with a single echo and a new multiple-echo gradient-echo sequence. Liver and muscle MR signal will be quantitatively determined and compared to biochemical assessment of liver iron concentration and steatosis quantification.

Conditions

• Iron Overload
• Metabolic Syndrome X
• Hepatitis B
• Hepatitis C
• Alcohol Abuse

Interventions

Type	Name	Description
DEVICE	Magnetic resonance imaging multiecho gradient-echo sequence	Breath-hold gradient echo sequences with a single echo and a new multiple-echo gradient-echo sequence

Timeline

• Start date: 2006-11-01
• Primary completion: 2013-03-01
• Completion: 2013-03-01
• First posted: 2006-11-20
• Last updated: 2023-05-24

Locations

10 sites across 2 countries: France, Spain