NCT00398723

Narrowband UVB Treatment in Patients With Vitiligo

Effects of Narrowband UVB Phototherapy on Melanocyte Proliferation in Patients With Vitiligo

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Mary Sullivan-Whalen · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The study offers narrowband UVB light therapy to patients who have 5% of their body involved with vitiligo. The hypothesis is that Narrowband UVB promotes melanocyte proliferation in vitiligo lesions.

Detailed description

All patients will receive phototherapy, with narrowband UVB, three times a week for six months, or a total of 78 treatments. 6mm punch skin biopsies (2) will be done prior to starting therapy, once during treatment (2) and at the completion of the study (2). Clinical assessments and photography will be done parallel to the skin biopsies. Results (clinically and histologically) will be analyzed.

Conditions

• Vitiligo

Interventions

Type	Name	Description
DEVICE	Narrowband UVB	Treatment three to seven times weekly for a total of 12 to 26 weeks (36 to 168 treatments). Dosing of NB-UVB will begin at 100-280 mJ/cm2, depending on tolerance and skin type, and will be titrated 10-20% per session until clinical efficacy or symptomatic erythema

Timeline

• Start date: 2006-11-01
• Primary completion: 2007-11-01
• Completion: 2007-11-01
• First posted: 2006-11-14
• Last updated: 2011-10-13

Locations

1 site across 1 country: United States