NCT00397592

Growth Hormone's Effect on Endothelial Progenitor Cells

The Effect of Exogenous Growth Hormone on the Mobilization of Endothelial Progenitor Cells

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 18 (actual)
• Sponsor: Vanderbilt University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

To assess the effect of short-term low-dose growth hormone therapy on the mobilization of endothelial progenitor cells from the bone marrow within a group of healthy adults.

Detailed description

We are proposing a pilot study to assess the effect of the administration of recombinant human growth hormone on the number of endothelial progenitor cells (EPC's) in the peripheral circulation. An increase in the number of EPC's is viewed as beneficial, as it has been postulated that they provide an endogenous repair mechanism to counteract endothelial injury. Additionally, a reduced number of EPC's has been found to independently predict atherosclerotic disease progression. Mechanisms proposed for enhancing the number of circulating EPC's and their function include an increase in proliferation, mobilization from the bone marrow, or prevention of EPC apoptosis. Thus, a pharmacologic manipulation of the number of EPC's in the peripheral circulation could potentially serve as a mechanism by which endothelial function, and thus vascular health, may be improved.

Conditions

• Cardiovascular Disease

Interventions

Type	Name	Description
DRUG	Growth Hormone

Timeline

• Start date: 2006-08-01
• Completion: 2007-01-01
• First posted: 2006-11-09
• Last updated: 2007-07-03

Locations

1 site across 1 country: United States