NCT00392275

Penetrance of Third Generation Fluoroquinolones in Eyes With Functioning Filtering Blebs

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 48 (planned)
• Sponsor: Indiana University School of Medicine · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Based on previous results with eyes without filtering blebs, the aqueous concentrations of ofloxacin and levofloxacin will exceed the concentration of ciprofloxacin after either topical or topical plus oral administration.

Detailed description

The purpose of this study is to assay human aqueous for concentrations of ofloxacin, ciprofloxacin and levofloxacin after topical or combined topical and oral administration in eyes with filtering blebs.

Conditions

• Cataract

Interventions

Type	Name	Description
DRUG	Ofloxacin 0.3%
DRUG	Ciprofloxacin 0.3%
DRUG	Levofloxacin 0.5%
DRUG	Ofloxacin 400mg
DRUG	Ciprofloxacin 400mg
DRUG	Levofloxacin 250mg

Timeline

• Start date: 2002-11-01
• Completion: 2006-05-01
• First posted: 2006-10-25
• Last updated: 2013-04-10

Locations

3 sites across 1 country: United States