NCT00385216

Nicotine as an Adjuvant Analgesic for Third Molar Surgery

Effect of Nicotine on Pain After Third Molar Extraction.

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Columbia University · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

Third molar surgery is complicated by pain and swelling for several days after surgery. Non-steroidal antiinflammatory drugs have been useful in combination with opioids for treatment. Nicotine has antiinflammatory and pain relieving properties. We will use nicotine or placebo as a nasal spray before surgery to determine whether nicotine affects pain or inflammation.

Detailed description

This is a randomized double blind cross-over study. In each of two sittings, the third molars on one side of the mouth are removed. In one sitting the subject will receive a nicotine nasal spray (3mg) and in the other placebo. VAS and narcotic utilization will be compared within patients.

Conditions

• Dental Crowding

Interventions

Type	Name	Description
DRUG	Nicotine	Nicotine nasal spray 3mg x 1 before surgery
OTHER	Placebo	Placebo nasal spray 0mg x 1 before surgery

Timeline

• Start date: 2004-07-01
• Primary completion: 2009-05-01
• Completion: 2009-06-01
• First posted: 2006-10-09
• Last updated: 2024-09-19
• Results posted: 2010-10-27

Locations

1 site across 1 country: United States