NCT00380640

The Efficacy of Trimethoprim in Wound Healing of Patients With Epidermolysis Bullosa

The Efficacy of Trimethoprim in Wound Healing of Patients With Epidermolysis Bullosa: A Randomized, Double Blinded, Placebo Controlled, Cross-over Pilot Study

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: The Hospital for Sick Children · Academic / Other
• Sex: All
• Age: 1 Day – 20 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to assess the efficacy of trimethoprim in promoting wound healing and decreasing blister formation in patients with Epidermolysis Bullosa.

Detailed description

Epidermolysis Bullosa (EB) comprises a series of hereditary disorders characterized by fragility of the skin and mucous membranes and the tendency of the skin to blister in response to minor friction or trauma. The care of patients with EB is a complex task that has to be carried out by a multi-professional team. In the absence of a cure, the goal of therapy is the prevention and healing of chronic wounds. In patients with EB, chronic inflammation interferes with proper wound healing. One treatment option is the use of anti-inflammatory antimicrobial agents, such as trimethoprim, to hasten wound healing and decrease blister formation. This treatment may lead to decreased pain and improvement of the quality of life for these patients.

Conditions

• Epidermolysis Bullosa

Interventions

Type	Name	Description
DRUG	Trimethoprim	This group will receive the active intervention (trimethoprim) first, followed by the placebo.
DRUG	Trimethoprim	This group will start the study with placebo, followed by the active intervention (trimethoprim).

Timeline

• Start date: 2006-09-01
• Primary completion: 2007-08-01
• Completion: 2007-09-01
• First posted: 2006-09-26
• Last updated: 2018-04-19

Locations

1 site across 1 country: Canada