NCT00378872

Tranexamic Acid vs. Quixil - Reducing Blood Loss in Joint Replacement

Prospective Randomised Trial Comparing Intraoperative Topical Quixil and Intravenous Tranexamic Acid, in Reduction of Blood Loss Following Primary Hip & Knee Joint Replacement Surgery.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 132 (actual)
• Sponsor: Golden Jubilee National Hospital · Other Government
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

We will compare the effectiveness of Quixil and Tranexamic acid in reducing bleeding during hip and knee joint replacements.

Detailed description

This is a prospective randomised controlled trial to compare the benefits of Quixil vs. Tranexamic acid in reducing blood loss. Both medicines are used for the reduction of blood loss in major joint surgery; previous studies have shown each one to be effective and safe, but they have not been directly compared in this setting. We will compare the blood loss in each of 3 groups: tranexamic acid used, Quixil used, and control group (neither drug used). Blood loss is to be calculated from height, body weight and difference between pre and post-operation haematocrit.

Conditions

• Hemorrhage
• Arthroplasty, Replacement, Hip
• Arthroplasty, Replacement, Knee

Interventions

Type	Name	Description
DRUG	IV Tranexamic acid 10mg/kg pt body weight
DRUG	Quixil topical sealant

Timeline

• Start date: 2006-06-01
• Primary completion: 2008-05-01
• Completion: 2008-05-01
• First posted: 2006-09-21
• Last updated: 2008-05-14

Locations

1 site across 1 country: United Kingdom